View source for 3fkc


==Crystal Structure of Human Zinc finger and BTB domain containing 33==
<StructureSection load='3fkc' size='340' side='right'caption='[[3fkc]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3fkc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FKC FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KAISO, ZBTB33, ZNF348 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fkc OCA], [https://pdbe.org/3fkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fkc RCSB], [https://www.ebi.ac.uk/pdbsum/3fkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fkc ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/KAISO_HUMAN KAISO_HUMAN]] Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2.<ref>PMID:11445535</ref> <ref>PMID:14527417</ref> <ref>PMID:15548582</ref> <ref>PMID:15817151</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fk/3fkc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fkc ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Bullock, A]]
[[Category: Burgess-Brown, N]]
[[Category: Delft, F von]]
[[Category: Edwards, A M]]
[[Category: Filippakopoulos, P]]
[[Category: Keates, T]]
[[Category: Knapp, S]]
[[Category: Muniz, J]]
[[Category: Structural genomic]]
[[Category: Weigelt, J]]
[[Category: Activator]]
[[Category: Dna-binding]]
[[Category: Kaiso transcription factor]]
[[Category: Metal-binding]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Repressor]]
[[Category: Sgc]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Wnt signaling pathway]]
[[Category: Wugsc:h_dj525n14 1]]
[[Category: Zinc finger and btb domain containing 33]]
[[Category: Zinc-finger]]
[[Category: Znf-kaiso]]
[[Category: Znf348]]