View source for 1qqr


==CRYSTAL STRUCTURE OF STREPTOKINASE DOMAIN B==
<StructureSection load='1qqr' size='340' side='right'caption='[[1qqr]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1qqr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_dysgalactiae_subsp._equisimilis Streptococcus dysgalactiae subsp. equisimilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QQR FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqr OCA], [https://pdbe.org/1qqr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qqr RCSB], [https://www.ebi.ac.uk/pdbsum/1qqr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qqr ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/STRP_STREQ STRP_STREQ]] This protein is not a protease, but it activates plasminogen by complexing with it. As a potential virulence factor, it is thought to prevent the formation of effective fibrin barriers around the site of infection, thereby contributing to the invasiveness of the cells. 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qq/1qqr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qqr ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptococcus dysgalactiae subsp. equisimilis]]
[[Category: Dobson, C]]
[[Category: Fox, V F]]
[[Category: Jones, E Y]]
[[Category: Phillips, C]]
[[Category: Ponting, C P]]
[[Category: Smith, R A.G]]
[[Category: Spraggon, G]]
[[Category: Stuart, D I]]
[[Category: Zhang, X X]]
[[Category: Fibrinolysis]]
[[Category: Hydrolase activator]]
[[Category: Non-proteolytic]]
[[Category: Plasminogen activation]]