View source for 1mvp


==STRUCTURAL STUDIES OF THE RETROVIRAL PROTEINASE FROM AVIAN MYELOBLASTOSIS ASSOCIATED VIRUS==
<StructureSection load='1mvp' size='340' side='right'caption='[[1mvp]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1mvp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Avima Avima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MVP FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mvp OCA], [https://pdbe.org/1mvp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mvp RCSB], [https://www.ebi.ac.uk/pdbsum/1mvp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mvp ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/GAG_AVIMA GAG_AVIMA]] Specifically liberates the five major structural proteins from the common gag precursor, as well as reverse transcriptase and integrase from the gag-pol precursor. 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mv/1mvp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mvp ConSurf].
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== Publication Abstract from PubMed ==
The structure of the retroviral proteinase from avian myeloblastosis associated virus (MAV) has been determined and refined at 2.2 A resolution. This structure is compared with those of homologous proteinases from Rous sarcoma virus (RSV) and human immunodeficiency type 1 virus (HIV). Through comparison with the structure of a proteinase-inhibitor complex from HIV, a model of a complex between MAV proteinase and a peptide substrate has been generated. Examination of this model suggests structural basis for the diverse specifications of viral proteinases.

Structural studies of the retroviral proteinase from avian myeloblastosis associated virus.,Ohlendorf DH, Foundling SI, Wendoloski JJ, Sedlacek J, Strop P, Salemme FR Proteins. 1992 Nov;14(3):382-91. PMID:1332025<ref>PMID:1332025</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Avima]]
[[Category: Large Structures]]
[[Category: Foundling, S I]]
[[Category: Ohlendorf, D H]]
[[Category: Salemme, F R]]