View source for 2vv4


==hPPARgamma Ligand binding domain in complex with 6-oxoOTE==
<StructureSection load='2vv4' size='340' side='right'caption='[[2vv4]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2vv4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VV4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6OB:(8E,10S,12Z)-10-HYDROXY-6-OXOOCTADECA-8,12-DIENOIC+ACID'>6OB</scene>, <scene name='pdbligand=6OC:(8R,9Z,12Z)-8-HYDROXY-6-OXOOCTADECA-9,12-DIENOIC+ACID'>6OC</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fvj|2fvj]], [[1fm9|1fm9]], [[2prg|2prg]], [[1knu|1knu]], [[1rdt|1rdt]], [[1i7i|1i7i]], [[3prg|3prg]], [[1k74|1k74]], [[1fm6|1fm6]], [[1zgy|1zgy]], [[1prg|1prg]], [[2f4b|2f4b]], [[2vst|2vst]], [[2g0h|2g0h]], [[2vsr|2vsr]], [[1wm0|1wm0]], [[4prg|4prg]], [[2g0g|2g0g]], [[1nyx|1nyx]], [[2vv0|2vv0]], [[2vv2|2vv2]], [[2vv3|2vv3]], [[2vv1|2vv1]]</div></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vv4 OCA], [https://pdbe.org/2vv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vv4 RCSB], [https://www.ebi.ac.uk/pdbsum/2vv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vv4 ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vv/2vv4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vv4 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) has important roles in adipogenesis and immune response as well as roles in both lipid and carbohydrate metabolism. Although synthetic agonists for PPARgamma are widely used as insulin sensitizers, the identity of the natural ligand(s) for PPARgamma is still not clear. Suggested natural ligands include 15-deoxy-delta12,14-prostaglandin J2 and oxidized fatty acids such as 9-HODE and 13-HODE. Crystal structures of PPARgamma have revealed the mode of recognition for synthetic compounds. Here we report structures of PPARgamma bound to oxidized fatty acids that are likely to be natural ligands for this receptor. These structures reveal that the receptor can (i) simultaneously bind two fatty acids and (ii) couple covalently with conjugated oxo fatty acids. Thermal stability and gene expression analyses suggest that such covalent ligands are particularly effective activators of PPARgamma and thus may serve as potent and biologically relevant ligands.

Structural basis for the activation of PPARgamma by oxidized fatty acids.,Itoh T, Fairall L, Amin K, Inaba Y, Szanto A, Balint BL, Nagy L, Yamamoto K, Schwabe JW Nat Struct Mol Biol. 2008 Sep;15(9):924-31. PMID:19172745<ref>PMID:19172745</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2vv4" style="background-color:#fffaf0;"></div>

==See Also==
*[[Peroxisome proliferator-activated receptor 3D structures|Peroxisome proliferator-activated receptor 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Fairall, L]]
[[Category: Itoh, T]]
[[Category: Schwabe, J W.R]]
[[Category: Ligand binding domain]]
[[Category: Nuclear receptor]]
[[Category: Oxidised fatty acid]]
[[Category: Receptor]]
[[Category: Transcription factor]]