View source for 1bas

[[Image:1bas.gif|left|200px]]<br />
<applet load="1bas" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1bas, resolution 1.9&Aring;" />
'''THREE-DIMENSIONAL STRUCTURES OF ACIDIC AND BASIC FIBROBLAST GROWTH FACTORS'''<br />

==Overview==
Members of the fibroblast growth factor (FGF) family of proteins stimulate, the proliferation and differentiation of a variety of cell types through, receptor-mediated pathways. The three-dimensional structures of two, members of this family, bovine acidic FGF and human basic FGF, have been, crystallographically determined. These structures contain 12 antiparallel, beta strands organized into a folding pattern with approximate threefold, internal symmetry. Topologically equivalent folds have been previously, observed for soybean trypsin inhibitor and interleukins-1 beta and -1, alpha. The locations of sequences implicated in receptor and heparin, binding by FGF are presented. These sites include beta-sheet strand 10, which is adjacent to the site of an extended sequence insertion in several, oncogene proteins of the FGF family, and which shows sequence conservation, among the FGF family and interleukin-1 beta.

==Disease==
Known diseases associated with this structure: Hypophosphatemic rickets, autosomal dominant OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=605380 605380]], Osteomalacia, tumor-induced OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=605380 605380]], Tumoral calcinosis, hyperphosphatemic, familial OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=605380 605380]]

==About this Structure==
1BAS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BAS OCA]. 

==Reference==
Three-dimensional structures of acidic and basic fibroblast growth factors., Zhu X, Komiya H, Chirino A, Faham S, Fox GM, Arakawa T, Hsu BT, Rees DC, Science. 1991 Jan 4;251(4989):90-3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1702556 1702556]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Chirino, A.J.]]
[[Category: Rees, D.C.]]
[[Category: growth factor]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:07:46 2007''