View source for 2he7


==FERM domain of EPB41L3 (DAL-1)==
<StructureSection load='2he7' size='340' side='right'caption='[[2he7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2he7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HE7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HE7 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EPB41L3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2he7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2he7 OCA], [https://pdbe.org/2he7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2he7 RCSB], [https://www.ebi.ac.uk/pdbsum/2he7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2he7 ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/E41L3_HUMAN E41L3_HUMAN]] Critical growth regulator in the pathogenesis of meningiomas. 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/2he7_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2he7 ConSurf].
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== Publication Abstract from PubMed ==
Perturbed cell-adhesion mechanisms are crucial for tumor invasion and metastasis. A cell-adhesion protein, Tumor Suppressor in Lung Cancer 1 (TSLC1), is inactivated in a majority of metastatic cancers. DAL-1 (differentially expressed in adenocarcinoma of the lung protein), another tumor suppressor, binds through its FERM domain to the TSLC1 C-terminal, 4.1 glycophorin C-like, cytoplasmic domain. However, the molecular basis for this interaction is unknown. Here, we describe the crystal structure of a complex between the DAL-1 FERM domain and a portion of the TSLC1 cytoplasmic domain. DAL-1 binds to TSLC1 through conserved residues in a well-defined hydrophobic pocket in the DAL-1 FERM domain's structural C-lobe. From the crystal structure, it is apparent that Tyr406 and Thr408 in the TSLC1 cytoplasmic domain form the most important interactions with DAL-1 and this was also confirmed by surface plasmon resonance studies. Our results refute earlier exon deletion experiments that indicated that glycophorin-C interacts with the alpha-lobe of 4.1 FERM domains.

Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B).,Busam RD, Thorsell AG, Flores A, Hammarstrom M, Persson C, Obrink B, Hallberg BM J Biol Chem. 2010 Dec 3. PMID:21131357<ref>PMID:21131357</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2he7" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C]]
[[Category: Berglund, H]]
[[Category: Busam, R D]]
[[Category: Collins, R]]
[[Category: Edwards, A]]
[[Category: Ehn, M]]
[[Category: Flodin, S]]
[[Category: Flores, A]]
[[Category: Graslund, S]]
[[Category: Hallberg, B M]]
[[Category: Hammarstrom, M]]
[[Category: Hogbom, M]]
[[Category: Johansson, I]]
[[Category: Karlberg, T]]
[[Category: Kotenyova, T]]
[[Category: Nilsson-ehle, P]]
[[Category: Nilvebrandt, J]]
[[Category: Norberg, P]]
[[Category: Nordlund, P]]
[[Category: Nyman, T]]
[[Category: Ogg, D]]
[[Category: Persson, C]]
[[Category: Structural genomic]]
[[Category: Sagemark, J]]
[[Category: Schiavone, L H]]
[[Category: Stenmark, P]]
[[Category: Sundstrom, M]]
[[Category: Thorsell, A G]]
[[Category: Uppenberg, J]]
[[Category: Weigelt, J]]
[[Category: Berg, S Van den]]
[[Category: Cell adhesion]]
[[Category: Dal-1]]
[[Category: Epb41l3a]]
[[Category: Ferm domain]]
[[Category: Sgc]]