View source for 2epr


==Solution structure of the secound zinc finger domain of Zinc finger protein 278==
<StructureSection load='2epr' size='340' side='right'caption='[[2epr]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2epr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EPR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PATZ1, PATZ, RIAZ, ZBTB19, ZNF278, ZSG ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2epr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2epr OCA], [https://pdbe.org/2epr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2epr RCSB], [https://www.ebi.ac.uk/pdbsum/2epr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2epr ProSAT], [https://www.topsan.org/Proteins/RSGI/2epr TOPSAN]</span></td></tr>
</table>
== Disease ==
[[https://www.uniprot.org/uniprot/PATZ1_HUMAN PATZ1_HUMAN]] Note=A chromosomal aberration involving PATZ1 is associated with small round cell sarcoma. Translocation t(1;22)(p36.1;q12) with EWSR1. 
== Function ==
[[https://www.uniprot.org/uniprot/PATZ1_HUMAN PATZ1_HUMAN]] Transcriptional repressor.<ref>PMID:10713105</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/2epr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2epr ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Zinc Fingers|Zinc Fingers]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Inoue, M]]
[[Category: Kigawa, T]]
[[Category: Muto, Y]]
[[Category: Structural genomic]]
[[Category: Shirouzu, M]]
[[Category: Suzuki, S]]
[[Category: Tanabe, W]]
[[Category: Terada, T]]
[[Category: Yokoyama, S]]
[[Category: C2h2]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rsgi]]
[[Category: Transcription]]
[[Category: Zinc finger domain]]