View source for 2edt


==Solution structure of the ig-like domain (3449-3537) from human Obscurin==
<StructureSection load='2edt' size='340' side='right'caption='[[2edt]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2edt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EDT FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">OBSCN ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2edt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2edt OCA], [https://pdbe.org/2edt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2edt RCSB], [https://www.ebi.ac.uk/pdbsum/2edt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2edt ProSAT], [https://www.topsan.org/Proteins/RSGI/2edt TOPSAN]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/OBSCN_HUMAN OBSCN_HUMAN]] Involved in myofibrillogenesis. Seems to be involved in assembly of myosin into sarcomeric A bands in striated muscle. Isoform 3 together with ANK1 isoform Mu17/Ank1.5 may provide a molecular link between the sarcoplasmic reticulum and myofibrils.<ref>PMID:11448995</ref> <ref>PMID:16205939</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/2edt_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2edt ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Obscurin|Obscurin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Hayashi, F]]
[[Category: Izumi, K]]
[[Category: Structural genomic]]
[[Category: Seimiya, K]]
[[Category: Yokoyama, S]]
[[Category: Yoshida, M]]
[[Category: Beta-sandwich]]
[[Category: Contractile protein]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Obscurin-mlck]]
[[Category: Obscurin-myosin light chain kinase]]
[[Category: Obscurin-rhogef]]
[[Category: Rsgi]]