View source for 2d92


==Solution structure of the fifth PDZ domain of InaD-like protein==
<StructureSection load='2d92' size='340' side='right'caption='[[2d92]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2d92]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D92 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">INADL, PATJ ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d92 OCA], [https://pdbe.org/2d92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d92 RCSB], [https://www.ebi.ac.uk/pdbsum/2d92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d92 ProSAT], [https://www.topsan.org/Proteins/RSGI/2d92 TOPSAN]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/INADL_HUMAN INADL_HUMAN]] Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons.<ref>PMID:11927608</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d9/2d92_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d92 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Hayashi, F]]
[[Category: Inoue, K]]
[[Category: Structural genomic]]
[[Category: Yokoyama, S]]
[[Category: Hinadl]]
[[Category: Inad-like protein]]
[[Category: Inadl]]
[[Category: Inadl protein]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Pals1-associated tight junction protein]]
[[Category: Patj]]
[[Category: Pdz domain]]
[[Category: Protein associated to tight junction]]
[[Category: Protein binding]]
[[Category: Rsgi]]