View source for 1dbh

[[Image:1dbh.gif|left|200px]]

<!--
The line below this paragraph, containing "STRUCTURE_1dbh", creates the "Structure Box" on the page.
You may change the PDB parameter (which sets the PDB file loaded into the applet) 
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
or leave the SCENE parameter empty for the default display.
-->
{{STRUCTURE_1dbh|  PDB=1dbh  |  SCENE=  }} 

'''DBL AND PLECKSTRIN HOMOLOGY DOMAINS FROM HSOS1'''


==Overview==
Proteins containing Dbl homology (DH) domains activate Rho-family GTPases by functioning as specific guanine nucleotide exchange factors. All known DH domains have associated C-terminal pleckstrin homology (PH) domains that are implicated in targeting and regulatory functions. The crystal structure of a fragment of the human Son of sevenless protein containing the DH and PH domains has been determined at 2.3 A resolution. The entirely alpha-helical DH domain is unrelated in architecture to other nucleotide exchange factors. The active site of the DH domain, identified on the basis of sequence conservation and structural features, lies near the interface between the DH and PH domains. The structure suggests that ligation of the PH domain will be coupled structurally to the GTPase binding site.

==About this Structure==
1DBH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DBH OCA]. 

==Reference==
Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein., Soisson SM, Nimnual AS, Uy M, Bar-Sagi D, Kuriyan J, Cell. 1998 Oct 16;95(2):259-68. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9790532 9790532]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Kuriyan, J.]]
[[Category: Soisson, S M.]]
[[Category: Guanine nucleotide exchange factor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:39:32 2008''