View source for 2bpw

[[Image:2bpw.gif|left|200px]]<br />
<applet load="2bpw" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="2bpw, resolution 2.8&Aring;" />
'''HIV-1 PROTEASE-INHIBITOR COMPLEX'''<br />

==Overview==
The ability to replace an inhibitor bound to the HIV-1 protease in single, crystals with other potent inhibitors offers the possibility of, investigating a series of protease inhibitors rapidly and conveniently, with the use of X-ray crystallography. This approach affords a fast, turnaround of structural information for iterative rational drug designs, and obviates the need for studying the complex structures by, co-crystallization. The replacement approach has been successfully used, with single crystals of the HIV-1 protease complexed with a weak, inhibitor. The structures of the complexes obtained by the replacement, method are similar to those determined by co-crystallization.

==About this Structure==
2BPW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with 1IN as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.13.16 3.4.13.16] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BPW OCA]. 

==Reference==
Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme., Munshi S, Chen Z, Li Y, Olsen DB, Fraley ME, Hungate RW, Kuo LC, Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):1053-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9757136 9757136]
[[Category: Deleted entry]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Single protein]]
[[Category: Chen, Z.]]
[[Category: Munshi, S.]]
[[Category: 1IN]]
[[Category: acid protease]]
[[Category: hydrolase]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Thu Nov  8 14:44:11 2007''