View source for 1pl9


==Crystal structure of KDO8P synthase in its binary complex with substrate analog Z-FPEP==
<StructureSection load='1pl9' size='340' side='right'caption='[[1pl9]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1pl9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1PL9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPE:3-FLUORO-2-(PHOSPHONOOXY)PROPANOIC+ACID'>FPE</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1g7u|1g7u]], [[1d9e|1d9e]], [[1phq|1phq]], [[1phw|1phw]], [[1q3n|1q3n]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KDSA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-deoxy-8-phosphooctulonate_synthase 3-deoxy-8-phosphooctulonate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.55 2.5.1.55] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1pl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pl9 OCA], [http://pdbe.org/1pl9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pl9 RCSB], [http://www.ebi.ac.uk/pdbsum/1pl9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pl9 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/KDSA_ECOLI KDSA_ECOLI]] Synthesis of KDO 8-P which is required for lipid A maturation and cellular growth.[HAMAP-Rule:MF_00056] 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pl/1pl9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pl9 ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Kdo-8-phosphate synthase|Kdo-8-phosphate synthase]]
__TOC__
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: 3-deoxy-8-phosphooctulonate synthase]]
[[Category: Large Structures]]
[[Category: Adir, N]]
[[Category: Baasov, T]]
[[Category: Belakhov, V]]
[[Category: Rabkin, E]]
[[Category: Vainer, R]]
[[Category: Beta-alpha-barrel]]
[[Category: Flourinated analog]]
[[Category: Lipopolysaccharide]]
[[Category: Lyase]]
[[Category: Transferase]]