View source for 1i2l


==DEOXYCHORISMATE LYASE FROM ESCHERICHIA COLI WITH INHIBITOR==
<StructureSection load='1i2l' size='340' side='right'caption='[[1i2l]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1i2l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2L OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1I2L FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DCS:D-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-N,O-CYCLOSERYLAMIDE'>DCS</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PABC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1i2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i2l OCA], [http://pdbe.org/1i2l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1i2l RCSB], [http://www.ebi.ac.uk/pdbsum/1i2l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1i2l ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PABC_ECOLI PABC_ECOLI]] Involved in the biosynthesis of p-aminobenzoate (PABA), a precursor of tetrahydrofolate. Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate.<ref>PMID:1644759</ref> <ref>PMID:2251281</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i2/1i2l_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i2l ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Large Structures]]
[[Category: Eisenstein, E]]
[[Category: Fisher, K E]]
[[Category: Howard, A J]]
[[Category: Jensen, P Y]]
[[Category: Ladner, J E]]
[[Category: Pachikara, A S]]
[[Category: Parsons, J F]]
[[Category: Tordova, M]]
[[Category: Aminodeoxychorismate]]
[[Category: D-cycloserine]]
[[Category: Lyase]]
[[Category: Pabc]]
[[Category: Pyridoxal phosphate]]