View source for 6vws


==Hexamer of Helical HIV capsid by RASTR method==
<StructureSection load='6vws' size='340' side='right'caption='[[6vws]], [[Resolution|resolution]] 6.08&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6vws]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VWS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VWS FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gag ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vws OCA], [http://pdbe.org/6vws PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vws RCSB], [http://www.ebi.ac.uk/pdbsum/6vws PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vws ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
The potent HIV-1 capsid inhibitor GS-6207 is an investigational principal component of long-acting antiretroviral therapy. We found that GS-6207 inhibits HIV-1 by stabilizing and thereby preventing functional disassembly of the capsid shell in infected cells. X-ray crystallography, cryo-electron microscopy, and hydrogen-deuterium exchange experiments revealed that GS-6207 tightly binds two adjoining capsid subunits and promotes distal intra- and inter-hexamer interactions that stabilize the curved capsid lattice. In addition, GS-6207 interferes with capsid binding to the cellular HIV-1 cofactors Nup153 and CPSF6 that mediate viral nuclear import and direct integration into gene-rich regions of chromatin. These findings elucidate structural insights into the multimodal, potent antiviral activity of GS-6207 and provide a means for rationally developing second-generation therapies.

Structural and mechanistic bases for a potent HIV-1 capsid inhibitor.,Bester SM, Wei G, Zhao H, Adu-Ampratwum D, Iqbal N, Courouble VV, Francis AC, Annamalai AS, Singh PK, Shkriabai N, Van Blerkom P, Morrison J, Poeschla EM, Engelman AN, Melikyan GB, Griffin PR, Fuchs JR, Asturias FJ, Kvaratskhelia M Science. 2020 Oct 16;370(6514):360-364. doi: 10.1126/science.abb4808. PMID:33060363<ref>PMID:33060363</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Asturias, F]]
[[Category: Iqbal, N]]
[[Category: Kvaratskhelia, M]]
[[Category: Vanblerkom, P]]
[[Category: Zhao, H]]
[[Category: Gs-6207 hexamer hiv]]
[[Category: Helical reconstruction]]
[[Category: Rastr]]
[[Category: Viral protein]]