View source for 5y05


==Structural characterization of msmeg_4306 from Mycobacterium smegmatis==
<StructureSection load='5y05' size='340' side='right'caption='[[5y05]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5y05]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y05 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5Y05 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5y05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y05 OCA], [http://pdbe.org/5y05 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y05 RCSB], [http://www.ebi.ac.uk/pdbsum/5y05 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y05 ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
The MSMEG_4306 gene from Mycobacterium smegmatis encodes a protein of unknown function with 242 amino-acid residues that contains a conserved zinc-ribbon domain at its C-terminus. Here, the crystal structure of MSMEG_4306 determined by the single-wavelength anomalous dispersion method using just one zinc ion co-purified with the protein is reported. The crystal structure of MSMEG_4306 shows a coiled-coil helix domain in the N-terminal region and a zinc-ribbon domain in the C-terminal region. A structural similarity search against the Protein Data Bank using MSMEG_4306 as a query revealed two similar structures, namely CT398 from Chlamydia trachomatis and HP0958 from Helicobacter pylori, although they share only approximately 15% sequence identity with MSMEG_4306. Based on comparative analysis, it is predicted that MSMEG_4306 may be involved in secretion systems, possibly by interacting with multiple proteins or nucleic acids.

Crystal structure of the MSMEG_4306 gene product from Mycobacterium smegmatis.,Kumar A, Karthikeyan S Acta Crystallogr F Struct Biol Commun. 2018 Mar 1;74(Pt 3):166-173. doi:, 10.1107/S2053230X18002236. Epub 2018 Feb 26. PMID:29497021<ref>PMID:29497021</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 5y05" style="background-color:#fffaf0;"></div>

==See Also==
*[[Kinesin 3D Structures|Kinesin 3D Structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Karthikeyan, S]]
[[Category: Kumar, A]]
[[Category: Coiled coil helix]]
[[Category: Hypothetical]]
[[Category: Unknown function]]
[[Category: Zinc ribbon]]
[[Category: Zinc-sad]]