View source for 7jtl


==Structure of SARS-CoV-2 ORF8 accessory protein==
<StructureSection load='7jtl' size='340' side='right'caption='[[7jtl]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7jtl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/2019-ncov 2019-ncov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JTL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7JTL FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jtl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jtl OCA], [http://pdbe.org/7jtl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jtl RCSB], [http://www.ebi.ac.uk/pdbsum/7jtl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jtl ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/NS8_SARS2 NS8_SARS2]] May play a role in host-virus interaction. 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The molecular basis for the severity and rapid spread of the COVID-19 disease caused by SARS-CoV-2 is largely unknown. ORF8 is a rapidly evolving accessory protein that has been proposed to interfere with immune responses. The crystal structure of SARS-CoV-2 ORF8 was determined at 2.04 A resolution by x-ray crystallography. The structure reveals a ~60 residue core similar to SARS-CoV ORF7a with the addition of two dimerization interfaces unique to SARS-CoV-2 ORF8. A covalent disulfide-linked dimer is formed through an N-terminal sequence specific to SARS-CoV-2, while a separate non-covalent interface is formed by another SARS-CoV-2-specific sequence, 73 YIDI 76 . Together the presence of these interfaces shows how SARS-CoV-2 ORF8 can form unique large-scale assemblies not possible for SARS-CoV, potentially mediating unique immune suppression and evasion activities.

Structure of SARS-CoV-2 ORF8, a rapidly evolving coronavirus protein implicated in immune evasion.,Flower TG, Buffalo CZ, Hooy RM, Allaire M, Ren X, Hurley JH bioRxiv. 2020 Aug 27. doi: 10.1101/2020.08.27.270637. PMID:32869027<ref>PMID:32869027</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7jtl" style="background-color:#fffaf0;"></div>

==See Also==
*[[Nonstructural protein 3D structures|Nonstructural protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: 2019-ncov]]
[[Category: Large Structures]]
[[Category: Allaire, M]]
[[Category: Buffalo, C Z]]
[[Category: Flower, T G]]
[[Category: Hooy, R M]]
[[Category: Hurley, J H]]
[[Category: Ren, X]]
[[Category: Accessory protein]]
[[Category: Coronavirus]]
[[Category: Covid-19]]
[[Category: Host-factor restriction]]
[[Category: Immune evasion]]
[[Category: Mhc-i]]
[[Category: Open reading frame 8]]
[[Category: Rna virus]]
[[Category: Sars-cov-2]]
[[Category: Sars2]]
[[Category: Viral protein]]