View source for 5m7b


==Blood group synthase AAGlyB in complex with UDP and cryoprotected with glycerol==
<StructureSection load='5m7b' size='340' side='right'caption='[[5m7b]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5m7b]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M7B OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5M7B FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zgf|3zgf]], [[3zgg|3zgg]], [[5m79|5m79]], [[5m7a|5m7a]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5m7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m7b OCA], [http://pdbe.org/5m7b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m7b RCSB], [http://www.ebi.ac.uk/pdbsum/5m7b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m7b ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN]] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity. 

==See Also==
*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rocha, J]]
[[Category: Royant, A]]
[[Category: Blood group synthase]]
[[Category: Cis-ab mutant]]
[[Category: Dual-specificity]]
[[Category: Glycosyltransferase]]
[[Category: Transferase]]