View source for 5hob


==p73 homo-tetramerization domain mutant I==
<StructureSection load='5hob' size='340' side='right'caption='[[5hob]], [[Resolution|resolution]] 1.22&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5hob]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HOB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5HOB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2kby|2kby]], [[4a9z|4a9z]], [[5hoc|5hoc]], [[2nb1|2nb1]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TP73, P73 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5hob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hob OCA], [http://pdbe.org/5hob PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hob RCSB], [http://www.ebi.ac.uk/pdbsum/5hob PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hob ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN]] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>  

==See Also==
*[[P73|P73]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Coutandin, D]]
[[Category: Dotsch, V]]
[[Category: Knapp, S]]
[[Category: Krojer, T]]
[[Category: Mathea, S]]
[[Category: Salah, E]]
[[Category: Hetero-tetramerization]]
[[Category: Homo-tetramerization mutant]]
[[Category: P73]]
[[Category: Tetramerization domain]]
[[Category: Transcription]]
[[Category: Transcription factor]]