View source for 5f36


==Crystal structure of the bromodomain of human ATAD2 in complex with Compound A12==
<StructureSection load='5f36' size='340' side='right'caption='[[5f36]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5f36]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F36 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5F36 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5UE:[(2~{R})-1-[(4-ETHANOYL-1,3-THIAZOL-2-YL)AMINO]-1-OXIDANYLIDENE-PROPAN-2-YL]AZANIUM'>5UE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ATAD2, L16, PRO2000 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5f36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f36 OCA], [http://pdbe.org/5f36 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f36 RCSB], [http://www.ebi.ac.uk/pdbsum/5f36 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f36 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>  

==See Also==
*[[ATPase family AAA domain-containing protein|ATPase family AAA domain-containing protein]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Adenosinetriphosphatase]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Caflisch, A]]
[[Category: Dong, J]]
[[Category: Hydrolase inhibitor complex]]
[[Category: Transferase]]