View source for 3j08


==High resolution helical reconstruction of the bacterial p-type ATPase copper transporter CopA==
<SX load='3j08' size='340' side='right' viewer='molstar' caption='[[3j08]], [[Resolution|resolution]] 10.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3j08]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arcfl Arcfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J08 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3J08 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">copA, pacS, AF_0473 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 ARCFL])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3j08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j08 OCA], [http://pdbe.org/3j08 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3j08 RCSB], [http://www.ebi.ac.uk/pdbsum/3j08 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3j08 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/COPA_ARCFU COPA_ARCFU]] Probably involved in copper and silver export.<ref>PMID:11756450</ref>  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
CopA uses ATP to pump Cu(+) across cell membranes. X-ray crystallography has defined atomic structures of several related P-type ATPases. We have determined a structure of CopA at 10 A resolution by cryo-electron microscopy of a new crystal form and used computational molecular docking to study the interactions between the N-terminal metal-binding domain (NMBD) and other elements of the molecule. We found that the shorter-chain lipids used to produce these crystals are associated with movements of the cytoplasmic domains, with a novel dimer interface and with disordering of the NMBD, thus offering evidence for the transience of its interaction with the other cytoplasmic domains. Docking identified a binding site that matched the location of the NMBD in our previous structure by cryo-electron microscopy, allowing a more detailed view of its binding configuration and further support for its role in autoinhibition.

The Architecture of CopA from Archeaoglobus fulgidus Studied by Cryo-Electron Microscopy and Computational Docking.,Allen GS, Wu CC, Cardozo T, Stokes DL Structure. 2011 Aug 3. PMID:21820315<ref>PMID:21820315</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3j08" style="background-color:#fffaf0;"></div>

==See Also==
*[[ATPase 3D structures|ATPase 3D structures]]
== References ==
<references/>
__TOC__
</SX>
[[Category: Arcfl]]
[[Category: Large Structures]]
[[Category: Allen, G S]]
[[Category: Cardozo, T]]
[[Category: Stokes, D L]]
[[Category: Wu, C]]
[[Category: Adenosine triphosphatase]]
[[Category: Archaeal protein]]
[[Category: Cation transport protein]]
[[Category: Copa]]
[[Category: Copper transporter]]
[[Category: Cryoelectron microscopy]]
[[Category: Hydrolase]]
[[Category: Metal transport]]
[[Category: P-type atpase]]