View source for 5bzr


==Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule==
<StructureSection load='5bzr' size='340' side='right'caption='[[5bzr]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5bzr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BZR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BZR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4XM:2-[3-(TETRAHYDRO-2H-PYRAN-4-YLOXY)PROPYL]-1,2,3,4-TETRAHYDROISOQUINOLIN-8-AMINE'>4XM</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5bzc|5bzc]], [[5bze|5bze]], [[5bzf|5bzf]], [[5bzg|5bzg]], [[5bzh|5bzh]], [[5bzi|5bzi]], [[5bzj|5bzj]], [[5bzm|5bzm]], [[5bzn|5bzn]], [[5bzo|5bzo]], [[5bzq|5bzq]], [[5bzp|5bzp]], [[5bzs|5bzs]], [[5bzt|5bzt]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cd44, Ly-24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bzr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bzr OCA], [http://pdbe.org/5bzr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bzr RCSB], [http://www.ebi.ac.uk/pdbsum/5bzr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bzr ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/CD44_MOUSE CD44_MOUSE]] Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing. 

==See Also==
*[[CD44|CD44]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Finzel, B C]]
[[Category: Liu, L K]]
[[Category: Link module]]
[[Category: Protein binding]]