View source for 6al2


==Crystal structure of E. coli YidC at 2.8 A resolution==
<StructureSection load='6al2' size='340' side='right'caption='[[6al2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6al2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AL2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AL2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">yidC, ECS88_4129 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6al2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6al2 OCA], [http://pdbe.org/6al2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6al2 RCSB], [http://www.ebi.ac.uk/pdbsum/6al2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6al2 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/YIDC_ECO45 YIDC_ECO45]] Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
YidC/Alb3/Oxa1 family proteins are involved in the insertion and assembly of membrane proteins. The core five transmembrane regions of YidC, which are conserved in the protein family, form a positively charged cavity open to the cytoplasmic side. The cavity plays an important role in membrane protein insertion. In all reported structural studies of YidC, the second cytoplasmic loop (C2 loop) was disordered, limiting the understanding of its role. Here, we determined the crystal structure of YidC including the C2 loop at 2.8A resolution with R/Rfree=21.8/27.5. This structure and subsequent molecular dynamics simulation indicated that the intrinsic flexible C2 loop covered the positively charged cavity. This crystal structure provides the coordinates of the complete core region including the C2 loop, which is valuable for further analyses of YidC.

2.8-A crystal structure of Escherichia coli YidC revealing all core regions, including flexible C2 loop.,Tanaka Y, Izumioka A, Abdul Hamid A, Fujii A, Haruyama T, Furukawa A, Tsukazaki T Biochem Biophys Res Commun. 2018 Oct 20;505(1):141-145. doi:, 10.1016/j.bbrc.2018.09.043. Epub 2018 Sep 18. PMID:30241934<ref>PMID:30241934</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6al2" style="background-color:#fffaf0;"></div>

==See Also==
*[[Insertase|Insertase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Large Structures]]
[[Category: Fujii, A]]
[[Category: Hamid, A A]]
[[Category: Izumioka, A]]
[[Category: Tanaka, Y]]
[[Category: Tsukazaki, T]]
[[Category: Chaperone]]
[[Category: Insertase]]
[[Category: Transmembrane]]