View source for 2cde


==Structure and binding kinetics of three different human CD1d-alpha- Galactosylceramide specific T cell receptors - iNKT-TCR==
<StructureSection load='2cde' size='340' side='right'caption='[[2cde]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2cde]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDE FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1b88|1b88]], [[1bwm|1bwm]], [[1h5b|1h5b]], [[1hxm|1hxm]], [[1ktk|1ktk]], [[1l0y|1l0y]], [[1tvd|1tvd]], [[2axh|2axh]], [[2axj|2axj]], [[2cdf|2cdf]], [[2cdg|2cdg]], [[1ao7|1ao7]], [[1qrn|1qrn]], [[1qse|1qse]], [[1qsf|1qsf]], [[1bd2|1bd2]], [[1lp9|1lp9]], [[1mi5|1mi5]], [[2bnr|2bnr]], [[2bnu|2bnu]], [[1kgc|1kgc]], [[1fo0|1fo0]], [[1kj2|1kj2]], [[1nam|1nam]], [[2ckb|2ckb]], [[1g6r|1g6r]], [[2bnq|2bnq]], [[1mwa|1mwa]], [[1kb5|1kb5]], [[1nfd|1nfd]], [[1tcr|1tcr]], [[1fyt|1fyt]], [[1j8h|1j8h]], [[1d9k|1d9k]], [[1ymm|1ymm]], [[1ypz|1ypz]], [[1zt4|1zt4]], [[1z5l|1z5l]], [[1zhn|1zhn]], [[2akr|2akr]], [[1cd1|1cd1]], [[1u3h|1u3h]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cde OCA], [http://pdbe.org/2cde PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cde RCSB], [http://www.ebi.ac.uk/pdbsum/2cde PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cde ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cde_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cde ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Invariant human TCR Valpha24-Jalpha18+/Vbeta11+ NKT cells (iNKT) are restricted by CD1d-alpha-glycosylceramides. We analyzed crystal structures and binding characteristics for an iNKT TCR plus two CD1d-alpha-GalCer-specific Vbeta11+ TCRs that use different TCR Valpha chains. The results were similar to those previously reported for MHC-peptide-specific TCRs, illustrating the versatility of the TCR platform. Docking TCR and CD1d-alpha-GalCer structures provided plausible insights into their interaction. The model supports a diagonal orientation of TCR on CD1d and suggests that complementarity determining region (CDR)3alpha, CDR3beta, and CDR1beta interact with ligands presented by CD1d, whereas CDR2beta binds to the CD1d alpha1 helix. This docking provides an explanation for the dominant usage of Vbeta11 and Vbeta8.2 chains by human and mouse iNKT cells, respectively, for recognition of CD1d-alpha-GalCer.

Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors.,Gadola SD, Koch M, Marles-Wright J, Lissin NM, Shepherd D, Matulis G, Harlos K, Villiger PM, Stuart DI, Jakobsen BK, Cerundolo V, Jones EY J Exp Med. 2006 Mar 20;203(3):699-710. Epub 2006 Mar 6. PMID:16520393<ref>PMID:16520393</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2cde" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Cerundolo, V]]
[[Category: Gadola, S D]]
[[Category: Harlos, K]]
[[Category: Jakobsen, B K]]
[[Category: Jones, E Y]]
[[Category: Koch, M]]
[[Category: Lissin, N M]]
[[Category: Marles-Wright, J]]
[[Category: Matulis, G]]
[[Category: Sheperd, D]]
[[Category: Stuart, D I]]
[[Category: Villiger, P M]]
[[Category: Alpha- galactosylceramide]]
[[Category: Cd1d]]
[[Category: Cell receptor]]
[[Category: Mhc class i]]
[[Category: Natural killer t cell]]
[[Category: T cell receptor]]
[[Category: Tcr]]