View source for 4w5c


==Crystal structure analysis of cruzain with three Fragments: 1 (N-(1H-benzimidazol-2-yl)-1,3-dimethyl-pyrazole-4-carboxamide), 6 (2-amino-4,6-difluorobenzothiazole) and 9 (N-(1H-benzimidazol-2-yl)-3-(4-fluorophenyl)-1H-pyrazole-4-carboxamide).==
<StructureSection load='4w5c' size='340' side='right'caption='[[4w5c]], [[Resolution|resolution]] 3.27&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4w5c]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W5C FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3H5:N-(1H-BENZIMIDAZOL-2-YL)-1,3-DIMETHYL-1H-PYRAZOLE-4-CARBOXAMIDE'>3H5</scene>, <scene name='pdbligand=3H6:N-(1H-BENZIMIDAZOL-2-YL)-3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE'>3H6</scene>, <scene name='pdbligand=3H7:4,6-DIFLUORO-1,3-BENZOTHIAZOL-2-AMINE'>3H7</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3kku|3kku]], [[4pi3|4pi3]], [[4pi4|4pi4]], [[4w5b|4w5b]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cruzipain Cruzipain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.51 3.4.22.51] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w5c OCA], [http://pdbe.org/4w5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4w5c RCSB], [http://www.ebi.ac.uk/pdbsum/4w5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4w5c ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR]] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group.  The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle. 

==See Also==
*[[Cruzain|Cruzain]]
__TOC__
</StructureSection>
[[Category: Cruzipain]]
[[Category: Large Structures]]
[[Category: Trycr]]
[[Category: Craik, C S]]
[[Category: McKerrow, J H]]
[[Category: Tochowicz, A]]
[[Category: Cruzain]]
[[Category: Cysteine protease]]
[[Category: Fragments-based drug discovery]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Mutagenesis]]
[[Category: Spr]]