View source for 2krr


==Solution structure of the RBD1,2 domains from human nucleolin==
<StructureSection load='2krr' size='340' side='right'caption='[[2krr]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2krr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KRR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KRR FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NCL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2krr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2krr OCA], [http://pdbe.org/2krr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2krr RCSB], [http://www.ebi.ac.uk/pdbsum/2krr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2krr ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/NUCL_HUMAN NUCL_HUMAN]] Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.<ref>PMID:10393184</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kr/2krr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2krr ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Nucleolin|Nucleolin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Arumugam, N]]
[[Category: Bates, P J]]
[[Category: Lane, A N]]
[[Category: Maliekal, J]]
[[Category: Miller, C]]
[[Category: Trent, J O]]
[[Category: Acetylation]]
[[Category: Cytoplasm]]
[[Category: Dna-binding]]
[[Category: Methylation]]
[[Category: Nuclear protein]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Rna-binding]]