View source for 1bz0

[[Image:1bz0.gif|left|200px]]<br />
<applet load="1bz0" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1bz0, resolution 1.50&Aring;" />
'''HEMOGLOBIN A (HUMAN, DEOXY, HIGH SALT)'''<br />

==Overview==
Hemoglobin Catonsville is a mutation of human hemoglobin (an alpha 2 beta, 2 tetramer) in which a glutamate residue is inserted into the first turn, of a highly conserved 3(10) helix (the C helix) of each alpha subunit. In, theory, amino acid insertions (or deletions) in protein helices can be, accommodated via two distinct mechanisms. One, termed the register shift, mechanism, preserves the geometry of the helix while requiring all of the, residues on one flank of the insertion site to rotate by 100 degrees in, the case of an alpha helix or by 120 degrees in the case of a 3(10) helix., The other, termed the bulge (or indentation) mechanism, distorts the local, geometry of the helix but does not alter the helix register., High-resolution X-ray diffraction analysis of deoxyhemoglobin Catonsville, shows that the inserted residue is accommodated as a bulge, demonstrating, that this is a viable mechanism. (In contrast, no such evidence is yet, available for the register shift mechanism.) More specifically, the, insertion converts one turn of the C helix from 3(10) geometry to alpha, helix-like geometry, raising the possibility that a common mechanism for, accommodating insertions and deletions within helices may involve, localized interconversions between 3(10), alpha, and pi helical, structures.

==About this Structure==
1BZ0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with HEM as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BZ0 OCA]. 

==Reference==
Accommodation of insertions in helices: the mutation in hemoglobin Catonsville (Pro 37 alpha-Glu-Thr 38 alpha) generates a 3(10)--&gt;alpha bulge., Kavanaugh JS, Moo-Penn WF, Arnone A, Biochemistry. 1993 Mar 16;32(10):2509-13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8448109 8448109]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Arnone, A.]]
[[Category: Kavanaugh, J.S.]]
[[Category: HEM]]
[[Category: oxygen transport]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Thu Nov  8 12:57:59 2007''