View source for 1ak4

[[Image:1ak4.jpg|left|200px]]

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{{STRUCTURE_1ak4|  PDB=1ak4  |  SCENE=  }} 

'''HUMAN CYCLOPHILIN A BOUND TO THE AMINO-TERMINAL DOMAIN OF HIV-1 CAPSID'''


==Overview==
The HIV-1 capsid protein forms the conical core structure at the center of the mature virion. Capsid also binds the human peptidyl prolyl isomerase, cyclophilin A, thereby packaging the enzyme into the virion. Cyclophilin A subsequently performs an essential function in HIV-1 replication, possibly helping to disassemble the capsid core upon infection. We report the 2.36 A crystal structure of the N-terminal domain of HIV-1 capsid (residues 1-151) in complex with human cyclophilin A. A single exposed capsid loop (residues 85-93) binds in the enzyme's active site, and Pro-90 adopts an unprecedented trans conformation. The structure suggests how cyclophilin A can act as a sequence-specific binding protein and a nonspecific prolyl isomerase. In the crystal lattice, capsid molecules assemble into continuous planar strips. Side by side association of these strips may allow capsid to form the surface of the viral core. Cyclophilin A could then function by weakening the association between capsid strips, thereby promoting disassembly of the viral core.

==About this Structure==
1AK4 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AK4 OCA]. 

==Reference==
Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid., Gamble TR, Vajdos FF, Yoo S, Worthylake DK, Houseweart M, Sundquist WI, Hill CP, Cell. 1996 Dec 27;87(7):1285-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8980234 8980234]
[[Category: Homo sapiens]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Protein complex]]
[[Category: Gamble, T R.]]
[[Category: Hill, C P.]]
[[Category: Sundquist, W I.]]
[[Category: Vajdos, F F.]]
[[Category: Worthylake, D K.]]
[[Category: Capsid]]
[[Category: Cyclophilin some]]
[[Category: Hiv-1]]
[[Category: Isomerase]]
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