View source for 4emx


==Crystal structure analysis of Human Serum Albumin in complex with chloride anions at cryogenic temperature==
<StructureSection load='4emx' size='340' side='right'caption='[[4emx]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4emx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EMX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EMX FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ao6|1ao6]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4emx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4emx OCA], [http://pdbe.org/4emx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4emx RCSB], [http://www.ebi.ac.uk/pdbsum/4emx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4emx ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>  
== Function ==
[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>  

==See Also==
*[[Albumin 3D structures|Albumin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bonilla, L]]
[[Category: Botti, H]]
[[Category: Buschiazzo, A]]
[[Category: Radi, R]]
[[Category: Trajtenberg, F]]
[[Category: All alpha]]
[[Category: Allostery]]
[[Category: Antioxidant]]
[[Category: Disulfide bond stabilized]]
[[Category: Drug binding]]
[[Category: Extracellular space]]
[[Category: Free radical]]
[[Category: Human plasma osmotic regulation]]
[[Category: Plasma]]
[[Category: Protein binding]]
[[Category: Redox biology]]
[[Category: Transport]]