View source for 4aw2


==Crystal structure of CDC42 binding protein kinase alpha (MRCK alpha)==
<StructureSection load='4aw2' size='340' side='right'caption='[[4aw2]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4aw2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AW2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=22E:5,11-DIMETHYL-1-OXO-2,6-DIHYDRO-1H-PYRIDO[4,3-B]CARBAZOL-9-YL+BENZOATE'>22E</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aw2 OCA], [http://pdbe.org/4aw2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4aw2 RCSB], [http://www.ebi.ac.uk/pdbsum/4aw2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4aw2 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/MRCKA_RAT MRCKA_RAT]] Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake.<ref>PMID:18854160</ref> <ref>PMID:21457715</ref> <ref>PMID:9418861</ref>  

==See Also==
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Azeez, K Abdul]]
[[Category: Bountra, C]]
[[Category: Delft, F von]]
[[Category: Edwards, A]]
[[Category: Elkins, J M]]
[[Category: Knapp, S]]
[[Category: Lafanechere, L]]
[[Category: Leung, T]]
[[Category: Muniz, J R.C]]
[[Category: Phillips, C]]
[[Category: Prudent, R]]
[[Category: Szklarz, M]]
[[Category: Tan, I]]
[[Category: Wang, J]]
[[Category: Cdc42bpa]]
[[Category: Transferase]]