View source for 4bli


==Galectin-3c in complex with Bisamido-thiogalactoside derivate 1==
<StructureSection load='4bli' size='340' side='right'caption='[[4bli]], [[Resolution|resolution]] 1.08&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4bli]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BLI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GMK:(3-DEOXY-3-(3-METHOXY-BENZAMIDO)-B-D-GALACTOPYRANOSYL)-(3-DEOXY-3-(3-METHOXY-BENZAMIDO)-2-O-SULFO-B-D-GALACTOPYRANOSYL)-SULFIDE'>GMK</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4blj|4blj]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bli OCA], [http://pdbe.org/4bli PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bli RCSB], [http://www.ebi.ac.uk/pdbsum/4bli PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bli ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>  

==See Also==
*[[Galectin 3D structures|Galectin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Engstrom, O]]
[[Category: Hakansson, M]]
[[Category: Leffler, H]]
[[Category: Logan, D T]]
[[Category: Nilsson, U J]]
[[Category: Noresson, A L]]
[[Category: Oberg, C T]]
[[Category: Immune system]]
[[Category: Lectin]]
[[Category: Sugar binding protein]]