View source for 6ntp


==PTP1B Domain of PTP1B-LOV2 Chimera==
<StructureSection load='6ntp' size='340' side='right'caption='[[6ntp]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ntp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NTP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NTP FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ntp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ntp OCA], [http://pdbe.org/6ntp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ntp RCSB], [http://www.ebi.ac.uk/pdbsum/6ntp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ntp ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Fox, J M]]
[[Category: Hongdusit, A]]
[[Category: Sankaran, B]]
[[Category: Zwart, P H]]
[[Category: Cancer]]
[[Category: Diabetes]]
[[Category: Hydrolase]]
[[Category: Obesity]]
[[Category: Protein phosphorylation]]
[[Category: Protein tyrosine phosphatase]]
[[Category: Signaling]]