View source for 6nnz


==Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 4==
<StructureSection load='6nnz' size='340' side='right'caption='[[6nnz]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6nnz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NNZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NNZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KUD:[(1S,2R)-2-(benzenecarbonyl)cyclopentyl]acetic+acid'>KUD</scene>, <scene name='pdbligand=KUG:[(1R,2S)-2-(benzenecarbonyl)cyclopentyl]acetic+acid'>KUG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6cve|6cve]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dethiobiotin_synthase Dethiobiotin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.3 6.3.3.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nnz OCA], [http://pdbe.org/6nnz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nnz RCSB], [http://www.ebi.ac.uk/pdbsum/6nnz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nnz ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/BIOD_MYCTU BIOD_MYCTU]] Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring.<ref>PMID:20565114</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Dethiobiotin synthase]]
[[Category: Large Structures]]
[[Category: Bruning, J B]]
[[Category: Polyak, S W]]
[[Category: Thompson, A P]]
[[Category: Wegener, K L]]
[[Category: Enzyme]]
[[Category: Nucleotide triphosphate binding]]
[[Category: Transferase]]