View source for 6c5n


==Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase with hydroxyoxamate inhibitor 1==
<StructureSection load='6c5n' size='340' side='right'caption='[[6c5n]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6c5n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staab Staab]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C5N FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=81B:(cyclopentylamino)(oxo)acetic+acid'>81B</scene>, <scene name='pdbligand=EN4:[cyclopentyl(hydroxy)amino](oxo)acetic+acid'>EN4</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ilvC, SAB1941 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273036 STAAB])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ketol-acid_reductoisomerase Ketol-acid reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.86 1.1.1.86] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c5n OCA], [http://pdbe.org/6c5n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c5n RCSB], [http://www.ebi.ac.uk/pdbsum/6c5n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c5n ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/ILVC_STAAB ILVC_STAAB]] Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. 

==See Also==
*[[Ketol-acid reductoisomerase 3D structures|Ketol-acid reductoisomerase 3D structures]]
__TOC__
</StructureSection>
[[Category: Ketol-acid reductoisomerase]]
[[Category: Large Structures]]
[[Category: Staab]]
[[Category: Guddat, L W]]
[[Category: Kandale, A]]
[[Category: McGeary, R P]]
[[Category: Patel, K M]]
[[Category: Schembri, M A]]
[[Category: Schenk, G]]
[[Category: You, L]]
[[Category: Zheng, S]]
[[Category: Inhibitor]]
[[Category: Isomerase]]
[[Category: Oxidoreductase]]