View source for 5uuv


==Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Bacillus anthracis in the complex with a product IMP and the inhibitor P182==
<StructureSection load='5uuv' size='340' side='right'caption='[[5uuv]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5uuv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UUV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8L1:N-{4-CHLORO-3-[4-(TRIFLUOROMETHYL)-1,3-THIAZOL-2-YL]PHENYL}-N-(2-{3-[(1E)-N-HYDROXYETHANIMIDOYL]PHENYL}PROPAN-2-YL)UREA'>8L1</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4myx|4myx]], [[4my8|4my8]], [[4my1|4my1]], [[4mya|4mya]], [[4qm1|4qm1]], [[4my9|4my9]], [[4mjm|4mjm]], [[3tsd|3tsd]], [[3usb|3usb]], [[3tsb|3tsb]], [[5urs|5urs]], [[5urr|5urr]], [[5uuw|5uuw]], [[5uuz|5uuz]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">guaB, GBAA_0008, A8C77_00065, ABW01_29210 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uuv OCA], [http://pdbe.org/5uuv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uuv RCSB], [http://www.ebi.ac.uk/pdbsum/5uuv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uuv ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/Q81W29_BACAN Q81W29_BACAN]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).[HAMAP-Rule:MF_01964] 

==See Also==
*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]]
__TOC__
</StructureSection>
[[Category: IMP dehydrogenase]]
[[Category: Large Structures]]
[[Category: Anderson, W F]]
[[Category: Structural genomic]]
[[Category: Gollapalli, D]]
[[Category: Gu, M]]
[[Category: Hedstrom, L]]
[[Category: Joachimiak, A]]
[[Category: Kim, Y]]
[[Category: Makowska-Grzyska, M]]
[[Category: Maltseva, N]]
[[Category: Mulligan, R]]
[[Category: Csgid]]
[[Category: Delta cb]]
[[Category: Impdh]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: Tim barrel]]