View source for 4zof


==Lobenzarit-like inhibitor bound in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)==
<StructureSection load='4zof' size='340' side='right'caption='[[4zof]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4zof]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycta Mycta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZOF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZOF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=59L:2-[(2-CARBOXY-5-NITROPHENYL)AMINO]-3-METHYLBENZOIC+ACID'>59L</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=PRP:ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC+ACID'>PRP</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4giu|4giu]], [[3qr9|3qr9]], [[4zoj|4zoj]], [[4zok|4zok]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">trpD, MRA_2208 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=419947 MYCTA])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Anthranilate_phosphoribosyltransferase Anthranilate phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.18 2.4.2.18] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zof OCA], [http://pdbe.org/4zof PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zof RCSB], [http://www.ebi.ac.uk/pdbsum/4zof PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zof ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/TRPD_MYCTA TRPD_MYCTA]] Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA). 

==See Also==
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
__TOC__
</StructureSection>
[[Category: Anthranilate phosphoribosyltransferase]]
[[Category: Large Structures]]
[[Category: Mycta]]
[[Category: Baker, E N]]
[[Category: Evans, G L]]
[[Category: Lott, J S]]
[[Category: Structural genomic]]
[[Category: Complex]]
[[Category: Inhibitor]]
[[Category: Lobenzarit-like analogue]]
[[Category: Magnesium binding]]
[[Category: Phosphoribosylpyrophosphate]]
[[Category: Phosphoribosyltransferase]]
[[Category: Prpp]]
[[Category: Tbsgc]]
[[Category: Transferase-transferase inhibitor complex]]