View source for 4wrc


==Crystal Structure of Surfactant Protein-A DEDN Mutant (E171D/P175E/R197N/K203D)==
<StructureSection load='4wrc' size='340' side='right'caption='[[4wrc]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4wrc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WRC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WRC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wre|4wre]], [[4wrf|4wrf]], [[4wr9|4wr9]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Sftpa1, Sftp-1, Sftp1, Sftpa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wrc OCA], [http://pdbe.org/4wrc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wrc RCSB], [http://www.ebi.ac.uk/pdbsum/4wrc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wrc ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/SFTPA_RAT SFTPA_RAT]] In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. 
__TOC__
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Cafarella, T R]]
[[Category: Head, J F]]
[[Category: McCormack, F X]]
[[Category: Nikolaidis, N M]]
[[Category: Rynkiewicz, M J]]
[[Category: Seaton, B A]]
[[Category: Wu, H]]
[[Category: Carbohydrate binding]]
[[Category: Collectin]]
[[Category: Lectin]]
[[Category: Lipid binding]]
[[Category: Sugar binding protein]]