View source for 6npf


==Structure of E.coli enolase in complex with an analog of the natural product SF-2312 metabolite.==
<StructureSection load='6npf' size='340' side='right'caption='[[6npf]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6npf]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NPF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KVM:[(3S)-1-hydroxy-2,5-dioxopyrrolidin-3-yl]phosphonic+acid'>KVM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6d3q|6d3q]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphopyruvate_hydratase Phosphopyruvate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.11 4.2.1.11] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6npf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6npf OCA], [http://pdbe.org/6npf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6npf RCSB], [http://www.ebi.ac.uk/pdbsum/6npf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6npf ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/ENO_ECO45 ENO_ECO45]] Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. 
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Phosphopyruvate hydratase]]
[[Category: Erlandsen, H]]
[[Category: Krucinska, J]]
[[Category: Lombardo, M]]
[[Category: Wright, D]]
[[Category: Complex]]
[[Category: Enolase]]
[[Category: Lyase]]
[[Category: Natural inhibitor]]
[[Category: Sf2312]]