View source for 1mzp


==Structure of the L1 protuberance in the ribosome==
<StructureSection load='1mzp' size='340' side='right'caption='[[1mzp]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1mzp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33909 Atcc 33909]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MZP FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ad2|1ad2]], [[1csj|1csj]], [[1dwu|1dwu]], [[1jj2|1jj2]], [[1giy|1giy]], [[1lnr|1lnr]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mzp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mzp OCA], [http://pdbe.org/1mzp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mzp RCSB], [http://www.ebi.ac.uk/pdbsum/1mzp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mzp ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/RL1_SULAC RL1_SULAC]] Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.  Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA (By similarity). 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mz/1mzp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mzp ConSurf].
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The L1 protuberance of the 50S ribosomal subunit is implicated in the release/disposal of deacylated tRNA from the E site. The apparent mobility of this ribosomal region has thus far prevented an accurate determination of its three-dimensional structure within either the 50S subunit or the 70S ribosome. Here we report the crystal structure at 2.65 A resolution of ribosomal protein L1 from Sulfolobus acidocaldarius in complex with a specific 55-nucleotide fragment of 23S rRNA from Thermus thermophilus. This structure fills a major gap in current models of the 50S ribosomal subunit. The conformations of L1 and of the rRNA fragment differ dramatically from those within the crystallographic model of the T. thermophilus 70S ribosome. Incorporation of the L1-rRNA complex into the structural models of the T. thermophilus 70S ribosome and the Deinococcus radiodurans 50S subunit gives a reliable representation of most of the L1 protuberance within the ribosome.

Structure of the L1 protuberance in the ribosome.,Nikulin A, Eliseikina I, Tishchenko S, Nevskaya N, Davydova N, Platonova O, Piendl W, Selmer M, Liljas A, Drygin D, Zimmermann R, Garber M, Nikonov S Nat Struct Biol. 2003 Feb;10(2):104-8. PMID:12514741<ref>PMID:12514741</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1mzp" style="background-color:#fffaf0;"></div>

==See Also==
*[[Ribosomal protein L1|Ribosomal protein L1]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Atcc 33909]]
[[Category: Large Structures]]
[[Category: Davydova, N]]
[[Category: Eliseikina, I]]
[[Category: Garber, M]]
[[Category: Liljas, A]]
[[Category: Nevskaya, N]]
[[Category: Nikonov, S]]
[[Category: Nikulin, A]]
[[Category: Piendl, W]]
[[Category: Platonova, O]]
[[Category: Selmer, M]]
[[Category: Tishchenko, S]]
[[Category: Zimmermann, R]]
[[Category: Ribosomal protein]]
[[Category: Ribosome]]
[[Category: Rna-protein complex]]