View source for 2fl8


==Fitting of the gp10 trimer structure into the cryoEM map of the bacteriophage T4 baseplate in the hexagonal conformation.==
<StructureSection load='2fl8' size='340' side='right'caption='[[2fl8]], [[Resolution|resolution]] 12.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2fl8]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpt4 Bpt4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FL8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FL8 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2fl9|2fl9]], [[2fkk|2fkk]], [[1s2e|1s2e]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 BPT4])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fl8 OCA], [http://pdbe.org/2fl8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fl8 RCSB], [http://www.ebi.ac.uk/pdbsum/2fl8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2fl8 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/VG10_BPT4 VG10_BPT4]] Structural component of the baseplate. 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fl/2fl8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fl8 ConSurf].
<div style="clear:both"></div>
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== Publication Abstract from PubMed ==
The success of tailed bacteriophages to infect cells far exceeds that of most other viruses on account of their specialized tail and associated baseplate structures. The baseplate protein gene product (gp) 10 of bacteriophage T4, whose structure was determined to 1.2 A resolution, was fitted into the cryo-electron microscopy structures of the pre and post-infection conformations of the virus. gp10 functions as a molecular lever that rotates and extends the hinged short tail fibers to facilitate cell attachment. The central folding motif of the gp10 trimer is similar to that of the baseplate protein gp11 and to the receptor-binding domain of the short tail fiber, gp12. The three proteins comprise the periphery of the baseplate and interact with each other. The structural and functional similarities of gp10, gp11, and gp12 and their sequential order in the T4 genome suggest that they evolved separately, subsequent to gene triplication from a common ancestor. Such events are usual in the evolution of complex organelles from a common primordial molecule.

Evolution of bacteriophage tails: Structure of T4 gene product 10.,Leiman PG, Shneider MM, Mesyanzhinov VV, Rossmann MG J Mol Biol. 2006 May 5;358(3):912-21. Epub 2006 Mar 9. PMID:16554069<ref>PMID:16554069</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2fl8" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bpt4]]
[[Category: Large Structures]]
[[Category: Leiman, P G]]
[[Category: Mesyanzhinov, V V]]
[[Category: Rossmann, M G]]
[[Category: Shneider, M M]]
[[Category: Bacteriophage t4]]
[[Category: Baseplate]]
[[Category: Evolution]]
[[Category: Gp10]]
[[Category: Structural comparison]]
[[Category: Tail]]
[[Category: Virus-viral protein complex]]