View source for 1uzr

[[Image:1uzr.gif|left|200px]]<br />
<applet load="1uzr" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1uzr, resolution 2.20&Aring;" />
'''CRYSTAL STRUCTURE OF THE CLASS IB RIBONUCLEOTIDE REDUCTASE R2F-2 SUBUNIT FROM MYCOBACTERIUM TUBERCULOSIS'''<br />

==Overview==
Two nrdF genes of Mycobacterium tuberculosis code for different R2, subunits of the class Ib ribonucleotide reductase (RNR). The proteins are, denoted R2F-1 and R2F-2 having 71% sequence identity. The R2F-2 subunit, forms the biologically active RNR complex with the catalytic R1E-subunit., We present the structure of the reduced R2F-2 subunit to 2.2 A resolution., Comparison of the R2F-2 structure with a model of R2F-1 suggests that the, important differences are located at the C-terminus. We found that within, class Ib, the E-helix close to the iron diiron centre has two preferred, conformations, which cannot be explained by the redox-state of the diiron, centre. In the R2F-2 structure, we also could see a mobility of alphaE in, between the two conformations.

==About this Structure==
1UZR is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with FE, CIT and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UZR OCA]]. 

==Reference==
Crystal structure of the biologically active form of class Ib ribonucleotide reductase small subunit from Mycobacterium tuberculosis., Uppsten M, Davis J, Rubin H, Uhlin U, FEBS Lett. 2004 Jul 2;569(1-3):117-22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15225619 15225619]
[[Category: Mycobacterium tuberculosis]]
[[Category: Single protein]]
[[Category: Davis, J.]]
[[Category: Rubin, H.]]
[[Category: Uhlin, U.]]
[[Category: Uppsten, M.]]
[[Category: CIT]]
[[Category: FE]]
[[Category: GOL]]
[[Category: r2f-2]]
[[Category: radical generation]]
[[Category: ribonucleotide reductase]]
[[Category: small subunit]]
[[Category: tuberculosis]]

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