View source for 6hsc


==Structure of Human Serum Albumin in complex with Aristolochic Acid at 1.9 A resolution==
<StructureSection load='6hsc' size='340' side='right'caption='[[6hsc]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6hsc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HSC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HSC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOQ:8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic+acid'>GOQ</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hsc OCA], [http://pdbe.org/6hsc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hsc RCSB], [http://www.ebi.ac.uk/pdbsum/6hsc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hsc ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>  
== Function ==
[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Grollman, A P]]
[[Category: Pomyalov, S]]
[[Category: Shoham, G]]
[[Category: Sidorenko, V S]]
[[Category: Aristolochic acid i]]
[[Category: Complex]]
[[Category: High resolution]]
[[Category: Human serum albumin]]
[[Category: Transport protein]]