View source for 6pu0


==Pigeon Cryptochrome4 bound to flavin adenine dinucleotide==
<StructureSection load='6pu0' size='340' side='right'caption='[[6pu0]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6pu0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Colli Colli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PU0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PU0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">A306_00007326 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8932 COLLI])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pu0 OCA], [http://pdbe.org/6pu0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pu0 RCSB], [http://www.ebi.ac.uk/pdbsum/6pu0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pu0 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Computational and biochemical studies implicate the blue-light sensor cryptochrome (CRY) as an endogenous light-dependent magnetosensor enabling migratory birds to navigate using the Earth's magnetic field. Validation of such a mechanism has been hampered by the absence of structures of vertebrate CRYs that have functional photochemistry. Here we present crystal structures of Columba livia (pigeon) CRY4 that reveal evolutionarily conserved modifications to a sequence of Trp residues (Trp-triad) required for CRY photoreduction. In ClCRY4, the Trp-triad chain is extended to include a fourth Trp (W369) and a Tyr (Y319) residue at the protein surface that imparts an unusually high quantum yield of photoreduction. These results are consistent with observations of night migratory behavior in animals at low light levels and could have implications for photochemical pathways allowing magnetosensing.

Chemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon.,Zoltowski BD, Chelliah Y, Wickramaratne A, Jarocha L, Karki N, Xu W, Mouritsen H, Hore PJ, Hibbs RE, Green CB, Takahashi JS Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19449-19457. doi:, 10.1073/pnas.1907875116. Epub 2019 Sep 4. PMID:31484780<ref>PMID:31484780</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6pu0" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Colli]]
[[Category: Large Structures]]
[[Category: Chelliah, Y]]
[[Category: Green, C B]]
[[Category: Hibbs, R E]]
[[Category: Hore, P J]]
[[Category: Jarocha, L]]
[[Category: Karki, N]]
[[Category: Mouritsen, H]]
[[Category: Takahashi, J S]]
[[Category: Wickramaratne, A C]]
[[Category: Zoltowski, B D]]
[[Category: Circadian clock protein]]
[[Category: Magnetosensor]]
[[Category: Photolyase]]