View source for 6jcs


==AAV5 in complex with AAVR==
<StructureSection load='6jcs' size='340' side='right'caption='[[6jcs]], [[Resolution|resolution]] 3.18&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6jcs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Adeno-associated_virus_-_5 Adeno-associated virus - 5] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JCS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JCS FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KIAA0319L, AAVR, KIAA1837, PP791 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jcs OCA], [http://pdbe.org/6jcs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jcs RCSB], [http://www.ebi.ac.uk/pdbsum/6jcs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jcs ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/K319L_HUMAN K319L_HUMAN]] Systemic lupus erythematosus;Limited cutaneous systemic sclerosis.  
== Function ==
[[http://www.uniprot.org/uniprot/K319L_HUMAN K319L_HUMAN]] Possible role in axon guidance through interaction with RTN4R.<ref>PMID:20697954</ref>  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Adeno-associated virus (AAV) receptor (AAVR) is an essential receptor for the entry of multiple AAV serotypes with divergent rules; however, the mechanism remains unclear. Here, we determine the structures of the AAV1-AAVR and AAV5-AAVR complexes, revealing the molecular details by which PKD1 recognizes AAV5 and PKD2 is solely engaged with AAV1. PKD2 lies on the plateau region of the AAV1 capsid. However, the AAV5-AAVR interface is strikingly different, in which PKD1 is bound at the opposite side of the spike of the AAV5 capsid than the PKD2-interacting region of AAV1. Residues in strands F/G and the CD loop of PKD1 interact directly with AAV5, whereas residues in strands B/C/E and the BC loop of PKD2 make contact with AAV1. These findings further the understanding of the distinct mechanisms by which AAVR recognizes various AAV serotypes and provide an example of a single receptor engaging multiple viral serotypes with divergent rules.

Divergent engagements between adeno-associated viruses with their cellular receptor AAVR.,Zhang R, Xu G, Cao L, Sun Z, He Y, Cui M, Sun Y, Li S, Li H, Qin L, Hu M, Yuan Z, Rao Z, Ding W, Rao Z, Lou Z Nat Commun. 2019 Aug 21;10(1):3760. doi: 10.1038/s41467-019-11668-x. PMID:31434885<ref>PMID:31434885</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6jcs" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Adeno-associated virus - 5]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Lou, Z]]
[[Category: Zhang, R]]
[[Category: Aav5]]
[[Category: Aavr]]
[[Category: Adeno-associated virus]]
[[Category: Receptor]]
[[Category: Virus]]