View source for 6ker


==Crystal structure of D113A mutant of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14 (DmGSTE14), in glutathione-bound form==
<StructureSection load='6ker' size='340' side='right'caption='[[6ker]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ker]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KER OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KER FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ker FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ker OCA], [http://pdbe.org/6ker PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ker RCSB], [http://www.ebi.ac.uk/pdbsum/6ker PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ker ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/GSTEE_DROME GSTEE_DROME]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). Essential for ecdysteroid biosynthesis (PubMed:25344753, PubMed:25300303). May be involved in detoxification (PubMed:22082028).<ref>PMID:22082028</ref> <ref>PMID:25300303</ref> <ref>PMID:25344753</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Glutathione transferase]]
[[Category: Large Structures]]
[[Category: Inaba, K]]
[[Category: Koiwai, K]]
[[Category: Morohashi, K]]
[[Category: Niwa, R]]
[[Category: Senda, T]]
[[Category: Yumoto, F]]
[[Category: Glutathione]]
[[Category: Glutathione s-transferase]]
[[Category: Gst]]
[[Category: Transferase]]