View source for 6h49


==A polyamorous repressor: deciphering the evolutionary strategy used by the phage-inducible chromosomal islands to spread in nature.==
<StructureSection load='6h49' size='340' side='right'caption='[[6h49]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6h49]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H49 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H49 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h49 OCA], [http://pdbe.org/6h49 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h49 RCSB], [http://www.ebi.ac.uk/pdbsum/6h49 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h49 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Stl is a master repressor encoded by Staphylococcus aureus pathogenicity islands (SaPIs) that maintains integration of these elements in the bacterial chromosome. After infection or induction of a resident helper phage, SaPIs are de-repressed by specific interactions of phage proteins with Stl. SaPIs have evolved a fascinating mechanism to ensure their promiscuous transfer by targeting structurally unrelated proteins performing identically conserved functions for the phage. Here we decipher the molecular mechanism of this elegant strategy by determining the structure of SaPIbov1 Stl alone and in complex with two structurally unrelated dUTPases from different S. aureus phages. Remarkably, SaPIbov1 Stl has evolved different domains implicated in DNA and partner recognition specificity. This work presents the solved structure of a SaPI repressor protein and the discovery of a modular repressor that acquires multispecificity through domain recruiting. Our results establish the mechanism that allows widespread dissemination of SaPIs in nature.

The structure of a polygamous repressor reveals how phage-inducible chromosomal islands spread in nature.,Rafael Ciges-Tomas J, Alite C, Humphrey S, Donderis J, Bowring J, Salvatella X, Penades JR, Marina A Nat Commun. 2019 Aug 15;10(1):3676. doi: 10.1038/s41467-019-11504-2. PMID:31417084<ref>PMID:31417084</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6h49" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Alite, C]]
[[Category: Bowring, J Z]]
[[Category: Ciges-Tomas, J R]]
[[Category: Donderis, J]]
[[Category: Marina, A]]
[[Category: Penades, J R]]
[[Category: Repressor]]
[[Category: Sapi]]
[[Category: Structural protein]]