View source for 5qt3


==Ground state model of human erythroid-specific 5'-aminolevulinate synthase, ALAS2 - SGC Diamond Xchem fragment screening==
<StructureSection load='5qt3' size='340' side='right'caption='[[5qt3]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5qt3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QT3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qt3 OCA], [http://pdbe.org/5qt3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qt3 RCSB], [http://www.ebi.ac.uk/pdbsum/5qt3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qt3 ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/HEM0_HUMAN HEM0_HUMAN]] X-linked sideroblastic anemia;Erythropoietic protoporphyria. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry. Gain of function mutations in ALS2 are responsible for XLDPT, but they can also be a possible aggravating factor in congenital erythropoietic porphyria and other erythropoietic disorders caused by mutations in other genes (PubMed:21309041).<ref>PMID:21309041</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: 5-aminolevulinate synthase]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Bailey, H]]
[[Category: Bezerra, G A]]
[[Category: Bountra, C]]
[[Category: Brandao-Neto, J]]
[[Category: Brennan, P E]]
[[Category: Delft, F von]]
[[Category: Douangamath, A]]
[[Category: Edwards, A]]
[[Category: Foster, W]]
[[Category: Krojer, T]]
[[Category: Nicola, B B]]
[[Category: Shrestha, L]]
[[Category: Talon, R]]
[[Category: Yue, W W]]
[[Category: Pandda]]
[[Category: Sgc - diamond i04-1 fragment screening]]
[[Category: Transferase]]
[[Category: Xchemexplorer]]