View source for 6isq


==structure of Lipase mutant with oxided Cys-His-Asp catalytic triad==
<StructureSection load='6isq' size='340' side='right'caption='[[6isq]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6isq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ISQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ISQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6isq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6isq OCA], [http://pdbe.org/6isq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6isq RCSB], [http://www.ebi.ac.uk/pdbsum/6isq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6isq ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/LIPB_PSEA2 LIPB_PSEA2]] Hydrolysis of triglycerides. Is very stereospecific both in hydrolysis and in organic synthesis and has a potentially important application in glucolipid synthesis. 
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</StructureSection>
[[Category: Large Structures]]
[[Category: Triacylglycerol lipase]]
[[Category: Cen, Y X]]
[[Category: Wu, Q]]
[[Category: Zhou, J H]]
[[Category: Calb]]
[[Category: Hydrolase]]