View source for GABA(A) receptor-associated protein

<StructureSection load='' size='400' side='right' caption='Human GABARAP (deep sky blue) complex with LIR peptide (green) (PDB entry [[4xc2]])' scene='77/775216/Cv/1'>


== Function ==

'''GABA(A) receptor-associated protein''' (GABARAP) is associated and promotes the clustering of GABA(A) receptors in fibroids<ref>PMID:10984509</ref>.  GABARAP interacts with the γ2 subunit of GABA(A) receptor<ref>PMID:9892355</ref>.  GABARAP transports GABA(A) receptors to the plasma membrane of neurons<ref>PMID:15601949</ref>.  '''GABARAP-like 1''' (GABARAPL1) is ubiquitin-like and it increases cell-surface expression of κ-type opioid receptor and is involved in the elongation of the phagophore membrane.

== Relevance ==

GABARAP is an autoantigen in stiff-person syndrome<ref>PMID:16984900</ref>.

== Structural highlights ==

The  <scene name='77/775216/Cv/2'>peptide which interacts with GABARAP is located between 2 hydrophobic pockets</scene><ref>PMID:25684205</ref>. <scene name='77/775216/Cv/3'>Interactions between GABARAP and LIR peptide</scene>.

== 3D Structures of GABA receptor-associated protein ==
[[GABA receptor-associated protein 3D structures]]

</StructureSection>
== 3D Structures of GABA receptor-associated protein ==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|

*GABARAP

**[[1gnu]], [[1kjt]], [[6hb9]] – hGABARAP – human<br />
**[[1kot]], [[1klv]], [[1km7]] – hGABARAP – NMR<br />
**[[3d32]] – hGABARAP + peptide<br />
**[[3dow]] – hGABARAP + calreticulin peptide<br />
**[[3wim]], [[4xc2]], [[5lxh]] – hGABARAP + LIR peptide<br />
**[[6a9x]], [[5yip]] – mGABARAP + Ankyrin-3 - mouse<br />
**[[5yir]] – mGABARAP + Ankyrin-2<br />

*GABARAPL1

**[[2r2q]] – hGABARAPL1<br />
**[[2l8j]], [[5dpt]], [[5lxi]], [[6hoi]], [[6hol]] – hGABARAPL1 + LIR peptide<br />

*GABARAPL2

**[[4co7]] – hGABARAPL2<br />
**[[6h8c]] – hGABARAPL2 + UBA5 - NMR<br />
}}
== References ==
<references/>
[[Category:Topic Page]]