View source for 5awc


==Crystal structure of human TLR8 in complex with MB-564==
<StructureSection load='5awc' size='340' side='right'caption='[[5awc]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5awc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AWC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AWC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=M4D:5-(4-AZANYLBUTYL)-3-PENTYL-QUINOLIN-2-AMINE'>M4D</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5awa|5awa]], [[5awb|5awb]], [[5awd|5awd]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TLR8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5awc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5awc OCA], [http://pdbe.org/5awc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5awc RCSB], [http://www.ebi.ac.uk/pdbsum/5awc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5awc ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref>  

==See Also==
*[[Toll-like Receptors|Toll-like Receptors]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Ohto, U]]
[[Category: Shimizu, T]]
[[Category: Tanji, H]]
[[Category: Adjuvant]]
[[Category: Glycosylation]]
[[Category: Immune system]]
[[Category: Linnate immunity]]
[[Category: Tlr8]]
[[Category: Vaccine adjuvant]]