View source for 4orb


==Crystal structure of mouse calcineurin==
<StructureSection load='4orb' size='340' side='right'caption='[[4orb]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4orb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ORB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ORB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4or9|4or9]], [[4ora|4ora]], [[4orc|4orc]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Calna, Ppp3ca ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Cnb, Ppp3r1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4orb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4orb OCA], [http://pdbe.org/4orb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4orb RCSB], [http://www.ebi.ac.uk/pdbsum/4orb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4orb ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PP2BA_MOUSE PP2BA_MOUSE]] Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L and HSPB1 (By similarity). Dephosphorylates SSH1.<ref>PMID:1328240</ref>  [[http://www.uniprot.org/uniprot/CANB1_MOUSE CANB1_MOUSE]] Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. 

==See Also==
*[[Calcineurin|Calcineurin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Phosphoprotein phosphatase]]
[[Category: Li, S J]]
[[Category: Ma, L]]
[[Category: Wang, J]]
[[Category: Wang, Z X]]
[[Category: Wu, J W]]
[[Category: Calmodulin-binding]]
[[Category: Hydrolase-metal binding protein complex]]